IndraLab

Statements

CYLD activates DUSP1. 5 / 6
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"Having shown that CYLD negatively regulates NTHi induced IL-8 expression via the inhibition of ERK and positively regulates MKP-1, we next investigated whether CYLD acts as a negative regulator for ERK dependent IL-8 induction via MKP-1."
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"CYLD also enhanced NTHi induced upregulation of MAP kinase phosphatase-1, which led to reduced ERK activation and subsequent suppression of IL-8."
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"Therefore, investigating the molecular mechanisms of how CYLD upregulates MKP-1 may bring new insights into the tight regulation of inflammatory responses."
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"Taken together, our data suggest that CYLD mediates NTHi induced upregulation of MKP-1."
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"Because CYLD has been identified as a DUB, we investigated whether DUB activity is required for the CYLD mediated upregulation of MKP-1 induced by NTHi."
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