IndraLab

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Cocaine inhibits FOS. 6 / 6
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"Since many acute behavioral responses to cocaine can require appropriate c-fos activation, it follows that loss of MSK1, which reduces cocaine induced H3 phosphorylation in striatum, as well as subsequent cocaine mediated locomotor sensitivity, results in the loss of cocaine mediated c-fos transcriptional activity."
21272014
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"Brain changes reported in homozygous 5-HT 1B KO mice do include reduced 5-HT levels, increased DA levels, and enhanced cocaine induced DA release in nucleus accumbens XREF_BIBR; reduced striatal SERT binding XREF_BIBR; reductions in 5-HT 2C receptor function XREF_BIBR; reduced cocaine induced c-fos elevation XREF_BIBR; and changes in several other receptor systems XREF_BIBR."
25514162
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"Repeated cocaine self administration also decreased c-Fos immunolabeling in the PVH, while repeated injections had no effect on c-Fos in this region."
26525566
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"In this regard, the results showed that adolescent cocaine exposure did not modulate cell proliferation (Ki-67+ cells) or c-Fos protein activation in the dentate gyrus region of the hippocampus, but attenuated c-Fos activation in the dorsal striatum."
30484727
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"Both MK801 and SCH23390 pre-treatments blocked acute cocaine induced c-Fos protein induction [P < 0.05]."
18822274
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"We observe enhanced cocaine reward when D1+ MSNs are activated optogenetically and when TrkB is deleted selectively from them, however, the latter results in decreased c-Fos induction by cocaine without a significant change in baseline neuronal excitability."
20947769