IndraLab

Statements

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"More importantly, we found that IL-1β decreased the expression of Kindlin-2 and CL further downregulated Kindlin-2 and upregulated Nlrp3 and Casp1 in IL-1β treated NP cells (Fig. 4j–m)."
35013104
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"Low extracellular Cl - levels cause ATP induced IL-1beta secretion, whereas Cl - channel blockers and high extracellular Cl - conditions inhibit NLRP3 activation."
33534121
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"Furthermore, targeting Cl channels only inhibited K -dependent canonical NLRP3 activation."
34094411
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"Since then, studies have demonstrated that Cl - channel inhibitors, including flufenamic acid, IAA94, DIDS, and NPPB, may inhibit NLRP3, but not AIM2 or NLRC4 inflammasome activation XREF_BIBR - XREF_BIBR."
30755589
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"In this study, by searching for kinds of lysine acetyltransferases inhibitors, we showed that SI-2 hydrochloride (SI-2), a specific inhibitor of lysine acetyltransferase KAT13B (lysine acetyltransferases 13B), specifically blocks NLRP3 inflammasome activation both in mice in vivo and in human cells ex vivo."
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