IndraLab

Statements

UBE2O ubiquitinates BAP1. 19 / 19
| 14 5
reach
"Strikingly, UBE2O ubiquitinates BAP1, and modified forms were more abundant in the C91S mutant."
24703950
reach
"UBE2O can also ubiquitinate the tumor-suppressive DUB BAP1 and regulate its subcellular localization and function in chromatin remodeling."
29562734
reach
"The reaction with methylated ubiquitin was as efficient as with the unmodified ubiquitin and resulted in a similar ubiquitination pattern, indicating that UBE2O multi-monoubiquitinates BAP1."
24703950
reach
"UBE2O monoubiquitinates multiple lysines on the BAP1 NLS, thereby inducing its cytoplasmic sequestration (45)."
35764170
reach
"Thus, substrate ubiquitination by UBE2O can induce cytoplasmic localization, which might be accompanied by further proteasomal degradation as a consequence of ubiquitin chain extension by other E3 lig[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24703950
reach
"Further, deletion of N or C terminal regions of UBE2O has been found to entirely disrupt ubiquitylation of BAP1 [XREF_BIBR]."
28659380
reach
"For example, UBE2O binds to and multi-monoubiquitinates BAP1 to induce its cytoplasmic localization and promotes adipocyte differentiation [XREF_BIBR]."
32901121
reach
"For example, UBE2O mediates multiple mono-ubiquitination of BAP1, a nuclear localization signal, and leads to its cytoplasmic sequestration [XREF_BIBR]."
28673317
reach
"While ubiquitination enzyme UBE2O monoubiquitinates the NLS of BAP1 and induces translocation (inactivation) of BAP1 from the nucleus to the cytoplasm, DUB activity of the UCH-domain of BAP1 counteracts the UBE2O activity mediated through the intramolecular interaction between the UCH-domain and COOH-terminal domain of BAP1."
26011428
reach
"Ubiquitination of BAP1 by UBE2O results in sequestration of BAP1 in the cytoplasm, rendering it unable to find its nuclear targets."
| PMC
reach
"Interaction with UBE2O is also lost, this corroborates with the UBE2O interaction site that is mapped to the C-terminus of BAP1 and that ubiquitination of BAP1 by UBE2O requires its NLS [26]."
| PMC
sparser
"Ubiquitination of BAP1 by UBE2O results in sequestration of BAP1 in the cytoplasm, rendering it unable to find its nuclear targets."
| PMC
sparser
"UBE2O can also ubiquitinate the tumor-suppressive DUB BAP1 and regulate its subcellular localization and function in chromatin remodeling ( xref )."
29562734
sparser
"Interaction with UBE2O is also lost, this corroborates with the UBE2O interaction site that is mapped to the C-terminus of BAP1 and that ubiquitination of BAP1 by UBE2O requires its NLS [ xref ]."
| PMC
reach
"Finally, we note that UBE2O, which we previously showed to directly monoubiquitinate BAP1 nuclear localization site (NLS) , is not involved in DEUBAD monoubiquitination (Supplementary Fig. 5c, d)."
30349006
sparser
"Strikingly, UBE2O ubiquitinates BAP1, and modified forms were more abundant in the C91S mutant ( Figure 1 C)."
24703950
sparser
"To further confirm that autodeubiquitination prevents accumulation of ubiquitin on BAP1, the bead-bound wild-type complex was pretreated with N-ethylmaleimide (NEM), which resulted in a significant ub[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24703950
reach
"In addition, UBE2O mediated multi monoubiquitylation of BAP1 sequesters this DUB to the cytoplasm during adipocyte differentiation [XREF_BIBR]."
33335288
reach
"UBE2O multi-monoubiquitinates the nuclear localization signal of BAP1, inducing its cytoplasmic sequestration [17]."
35668470