IndraLab

Statements

FBP1 activates USP29. 3 / 3
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"In addition, a recent study revealed that AIMP2–FBP1 complex transcriptionally activates USP29 in oxidative conditions [ xref ]."
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"USP29 is induced by JTV1 and FBP driven transcription in response to oxidative stress, and was also shown to be important for the full activation of PUMA and apoptosis [XREF_BIBR]."
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"It will be interesting to examine whether DX2 also competes with AIMP2 and p38 for binding to FBP1 and inhibits FBP1 mediated induction of USP29, which in turn, may have destabilizing effect on p53."
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