IndraLab

Statements

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"Through a biochemical screen, we identified BAP1 catalytic inhibitors that inhibit truncated-ASXL1-driven leukemic gene expression and impair tumor progression in vivo."
35122023
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"In the prevailing model, nuclear BAP1 activates gene expression by deubiquitinating H2AK119Ub and safeguards Polycomb-mediated repression by removing any misplaced H2AK119Ub (5-8)."
36865140
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"In this study, we identified a key signaling pathway involving the histone H2AK119 deubiquitinase BRCA1 associated protein 1 (BAP1), the interferon regulatory factor interferon regulatory factor 1 (IRF1), and the MHC-II transactivator class II transactivator (CIITA), which directly activates MHC-II gene expression."
39817454
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"Meta-analyses have indicated that mutations in PBRM1 and SETD2 tend to occur together, but mutations in PBRM1 and BAP1 tend to be mutually exclusive and are thought to underlie different pathologic fe[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27664394
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"Collectively, these results indicated that BAP1 may directly regulate MHC-II cluster gene expression, and this regulatory effect is independent of cell types."
39817454
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"Based on our independent analysis, BAP1 deficiency in myeloid progenitors led to a dramatic increase of H3K27me3 levels at the MHC-II loci (Supplemental Figure 2G), and a substantial reduction in MHC-II gene expression (Supplemental Figure 2, H and I), which is consistent with our conclusions."
39817454
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"Although BAP1 can directly regulate gene expression, this pattern suggests critical epigenetic roles for BAP1 during ENS cell lineage specification."
38690732
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"Furthermore, our findings that BaP1 induced gene expression of COX-2 and mPGES-1 demonstrate that BaP1 can trigger transcriptional mechanisms in FLSs that result in increased protein expression."
32094439
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"BAP1 deubiquitinating enzymatic activity is an important modulator of gene expression."
36672131