IndraLab

Statements

Cystine increases the amount of USP18. 3 / 3
| 3
reach
"Strikingly, complete cystine deprivation increased the levels of SLC7A11 and USP18, but decreased the levels of KCTD10 in a time-dependent manner (Fig. 5A)."
38959043
reach
"Specifically, cystine deprivation increases the levels of both SLC7A11 and USP18 but decreases KCTD10 levels, which is reversible by cystine addition."
40440083
reach
"Here we showed a dynamic regulation of the SLC7A11 stability by KCTD10 and USP18 in response to cystine levels in the culture, as evidenced by 1) cystine deprivation decreases the levels of KCTD10, but increases the levels of USP18, which is reversed/rescued by cystine resupply, and 2) cystine deprivations disrupts the SLC7A11–KCTD10 interaction to reduce SLC7A11 ubiquitylation, whereas increases the SLC7A11–USP18 interaction to enhance SLC7A11 deubiquitylation."
38959043