IndraLab

Statements

USP9X inhibits TP53. 6 / 6
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"USP9X deficient cells promoted p53 degradation suggesting it to be considered as a potential therapeutic modulator in p53 related tumors."
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"miR-26b enhances the sensitivity of hepatocellular carcinoma to Doxorubicin via USP9X dependent degradation of p53 and regulation of autophagy."
33767588
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"In conclusion, this study revealed that miR-26b regulation was a mechanism involved in the sensitivity of HCC cell lines to doxorubicin directly through USP9X dependent degradation of p53 and regulation of autophagy."
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"We found that HepG2 (p53 wild-type) pretreated with Tenovin-1 by 2 h displayed the decreased doxorubicin sensitivity in the presence of WP1130, indicating that stabilization of p53 abolished the effec[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"WP1130 also increases sensitivity to doxorubicin via degrading p53 by a USP9X dependent mechanism in HCC cells XREF_BIBR."
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"It also confers doxorubicin sensitivity of hepatocellular carcinoma through USP9X dependent degradation of p53 [XREF_BIBR]."
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