IndraLab

Statements

reach
"Furthermore, Decitabine markedly reduced phospho-IkappaBalpha and nuclear NF-kappaB-p65, strongly suggesting that Decitabine inhibits activation of the NF-kappaB pathway."
32714333
reach
"In conclusion, our study demonstrates that low-dose decitabine induces degradation of IkappaBalpha by beta-TrCP through a proteasome degradation pathway, to boost NF-kappaB activation and thus promotes the proliferation of IFN-gamma + CD4 + T cells and enhances the anti-tumor immune activity of CD4 + T cells (XREF_FIG)."
33791306
reach
"These results suggest that low-dose decitabine potentiates NF-kappaB activation in CD4 + T cells by enhancing beta-TrCP expression and mediated IkappaBalpha degradation."
33791306