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Ubiquitin activates OTULIN. 1 / 2

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"Hence, we reveal a mechanism of substrate assisted catalysis in which Glu16 of the proximal Ub activates the catalytic triad of OTULIN by both restricting the movement of the catalytic His339 and introducing a negative charge, presumably for the proper coordination of Asn341 for catalysis."

23746843

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Ubiquitin activates OTULIN. 1 / 2

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