IndraLab

Statements

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"A previous study XREF_BIBR demonstrated that downregulation of PSMD7 led to decreased cell proliferation and increased apoptosis in esophageal squamous cell carcinoma."
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"Studies have demonstrated that PSMD7 silencing induces proliferation inhibition and apoptosis of ESCC cells, and results in cell cycle arrest, cell senescence, and apoptosis in breast cancer cells18, 19."
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"Meanwhile, it was associated with increased expression of cleaved PARP and stronger staining of cleaved caspase-3 after PSMD7 inhibition, suggesting that cell apoptosis was induced by PSMD7 knockdown invivo."
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"Previous studies reported that PSMD7 is a substrate of USP14, and PSMD7 downregulation induces apoptosis and suppresses tumorigenesis of esophageal squamous cell carcinoma via the mTOR/p70S6K pathway, thus, we speculated USP14 regulates mTOR/p70S6K pathway via the interaction with PSMD7."
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"PSMD7 promotes cell cycle progression and suppresses cell senescence and apoptosis of breast cancer cells by regulating the stability of p21 and p2719."
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"PSMD7 knockdown inhibits cell proliferation and induces cell cycle arrest, cell senescence and apoptosis by activating the p53 pathway in lung adenocarcinoma cells [ 16 ]."
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"Similarly, RAB1A overexpression reversed PSMD7 knockdown-induced apoptosis and invasion inhibition in the T24 cells ( P < 0.05, Fig. 7 C and D)."
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"Knockdown of PSMD7 inhibits tumorigenesis and induces cell apoptosis in esophageal squamous cell carcinoma (ESCC) via the mTOR and p70S6K pathway [XREF_BIBR]."
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"PSMD7 promoted cell viability, apoptosis resistance, and DNA damage repair in GC cells upon cisplatin (DDP) treatment."
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"Knockdown of PSMD7 induces cell cycle arrest, senescence, and apoptosis by regulating cell cycle proteins and the p53 pathway in lung cancer cells."
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"Knockdown of PSMD7 induces apoptosis and inhibits tumorigenesis in esophageal squamous cell carcinoma XREF_BIBR."
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"PSMD7 downregulation induces apoptosis and suppresses tumorigenesis of esophageal squamous cell carcinoma via the mTOR and p70S6K pathway."
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"Downregulation of PSMD7 by lentivirus mediated shRNA led to decreased proliferation, increased cell apoptosis, and reduced proteasomal function."
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"Furthermore, PSMD7 downregulation contributed to decelerated tumor growth, inhibition of proteasomal function, induced cell apoptosis and attenuated activity of mTOR and p70S6K pathway invivo."
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"Knockdown of PSMD7 showed inhibited proliferation and enhanced apoptosis, which is through mTOR and p70S6K signaling pathway."
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