IndraLab

Statements

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"The lack of BAP1 was shown to increase genome instability and alter the response to microtubule targeting agents [67]."
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"Importantly though, we observed a number of extra mitotic phenotypes upon depletion of BAP1 that did not occur upon BRCA1 depletion indicating the presence of additional mechanisms through which BAP1 may contribute to mitotic progression and genome stability (Fig. 7)."
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"Deletion or heterozygous loss of Bap1 in murine pancreata causes genomic instability, tissue damage, and pancreatitis with full penetrance."
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"The loss of BAP1 also impairs the DNA damage response and increases genomic instability."
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"Low BAP1 expression promotes genomic instability by failing to regulate DNA repair pathways or by altering the expression of other tumor suppressor genes, contributing to an aggressive cancer phenotype."
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"The complement factor H-related (CFHR) protein family induces the ubiquitination of polo-like kinase 1 (PLK1) at lysine 209 (Zhu et al., 2021a), BRCA1-associated protein 1 (BAP1) enhances genomic stability (Perkail et al., 2020), and USP9X is found to restrain tumor growth in the patient-derived tumor xenograft (PDX) model (Pal et al., 2018)."
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