IndraLab
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Mutated BAP1 inhibits Neoplasm Invasiveness. 1 / 1
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"Given the critical role of HIF-1alpha in promoting tumor invasion, we propose that: 1) Reduced BAP1 in the tumor cells and tumor microenvironment of individuals carrying germline BAP1 mutations may contribute to the reduced invasion and the significantly improved prognosis of mesothelioma; 2) targeting wild-type BAP1 after tumor development could be a novel effective strategy to reduce HIF-1alpha protein levels in hypoxic tissues and impair tumor growth."