IndraLab

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SIRT1 activates USP22. 4 / 4
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"This suggested SIRT1 might be a mediator of miR-144-3p/USP22 in regulating the ferroptosis of INS-1 cells."
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"In addition, SIRT1 is a functional mediator of USP22, and USP22 promotes the expression of SIRT1 by directly combining with SIRT1."
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"Interestingly , Sirt-1 also activates USP22 expression through activation of c-Myc [ 34 ] , suggesting that a positively regulatory loop exists between Sirt-1 and USP22 ."
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"On the other hand, by downregulating USP22, the RAS system can reduce Sirt 1 protein expression (Wang et al., 2021)."
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