IndraLab

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"Interestingly, in another study where EGCG blocked the UVB induced c-Fos activation in a human keratinocyte cell line HaCaT, inhibition of p38 activation was suggested as the major mechanism underlying the effects of EGCG [XREF_BIBR]."

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"Therefore, EGCG inhibits c-Fos, a component of AP-1, to inhibit cell proliferation and cell survival."

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"It was found that EGCG directly blocks c-Fos cytoplasmic to nuclei signal translocation after interactions of AL light chains with mesangial cells, resulting in a decrease in amyloid formation."

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"Reporter assays indicated that both EGCG and Poly E inhibited the transcriptional activity of the activator protein 1 (AP-1), c-fos, nuclear factor kappaB, and cyclin D1 promoters."