
IndraLab
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"A plausible explanation for this is that MK3 promotes phosphorylation of eIF2α (without eIF2α being a direct substrate of MK3), whereas MK2 inhibits this function of MK3, similar to that reported for the regulation of IRF3, IFNβ, IL10, IκBβ, and IκBα in macrophages where MK2 also prevented MK3 from exerting negative regulatory effects xref (cf. xref )."