IndraLab

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OTUD5 inhibits GPX4. 2 / 2

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"In conclusion, these results demonstrated that OTUD5 mediates the K48‐linked deubiquitination of GPX4 and stabilises GPX4.2.3 OTUD5 suppresses ferroptosis via GPX4."

40070026

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"Overall, this study highlights a new autophagy-dependent ferroptosis module: hypoxia/ischemia-induced OTUD5 autophagy triggers GPX4 degradation, offering a potential therapeutic avenue for I/R-related kidney diseases."

38110369

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IndraLab

Statements

OTUD5 inhibits GPX4. 2 / 2

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