IndraLab

Statements

HSPA inhibits KCNH2. 2 / 2
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"In contrast, another member of the Hsp70 family, heat shock cognate protein 70 (Hsc70) was shown to initiate degradation of hERG and CFTR [11,12]."
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"Here, we demonstrate that the Hsp70 nucleotide exchange factor Bag1 promotes hERG degradation by the ubiquitin-proteasome system at the endoplasmic reticulum to regulate hERG levels and channel activity."
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