IndraLab
Statements
reach
"Stress reduced levels of IL-4 and IL-10, two major anti-inflammatory cytokines, were restored back to normal by agmatine treatment in the PFC. The findings of the present study suggest that stress activated NLRP3 inflammasome and cytokine responses are reversed by an acute administration of agmatine."
reach
"Agmatine significantly down-regulated the gene expressions of all stress induced NLRP3 inflammasome components (NLRP3, NF-kappaB, PYCARD, caspase-1, IL-1beta and IL-18) in the hippocampus and prefrontal cortex (PFC) and reduced pro inflammatory cytokine levels not only in both brain regions, but also in serum."