IndraLab

Statements

Sitosterol inhibits DDX58. 5 / 5
| 4 1
reach
"These results suggest that beta-sitosterol treatment antagonizes the RIG-I signaling cascades."
| PMC
sparser
"To examine the effect of RIG-I inhibition by β-sitosterol on the transcription of IFN signaling-related molecules, we analyzed IAV-mediated IFN-stimulated response element (ISRE) activation with an assay that utilized a transient ISRE reporter plasmid."
| PMC
reach
"Our results show that beta-sitosterol decreased the induction of RIG-I in infected A549 cells."
| PMC
reach
"Collectively, these data suggest that beta-sitosterol inhibits the activation of RIG-I signaling and downstream apoptosis in response to vRNA."
| PMC
reach
"Therefore, the inhibition of STAT1 phosphorylation in response to IFN-beta treatment for 15min or 24h can be attributed to the downregulation of RIG-I by beta-sitosterol."
| PMC