IndraLab

Statements

USP4 activates RBBP8. 4 / 4
| 4
reach
"As shown in Figures 5 A-5D, WT USP4, but not the insert domain deletion mutant, restored CtIP and downstream RAD51 and RPA foci in USP4 depleted cells after IR."
26387952
reach
"In addition, auto-deubiquitination of USP4 has been shown to stimulate homologous recombination and its interaction with CtIP to recruit CtIP to DNA damage sites, suggesting ubiquitination-dependent regulation of DUB enzyme interaction and function."
37642399
reach
"Existing studies have shown that auto-deubiquitylation of USP4 enhances its interaction with CtIP/MRN, thereby promoting homologous recombination (33)."
39303916
reach
"Rather, there are additional routes for the initiation of HR via enhancing DSB end resection, wherein p75 (50), USP4 (51) or AUNIP (52) interacts with CtIP, promoting CtIP accumulation at DSBs for efficient end resection and HR."
31340001