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OTUB1 inhibits conjugation. 2 / 2
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"In that respect, OTUB1 was described recently to inhibit Ub chain conjugation, independently of its catalytic activity, through direct binding to the E2 ubiquitin-conjugating enzyme UBC13 (Nakada et al, 2010)."
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"However, we cannot categorically rule out involvement of UBCH5a/b because residual activities in the cytosol fractions could be sufficient for ubiquitylation.Our data suggest that OTUB1 prevents accum[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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