IndraLab

Statements

BAP1 inhibits PROS1. 5 / 5
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"Inactivation of BAP1 promotes the upregulation of vitamin K-dependent protein S ( PROS1 ) , which interacts with the tyrosine-protein kinase Mer ( MERTK ) receptor on M2 macrophages to induce an immunosuppressive environment ."
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"Loss of BAP1 could promote the immunosuppressive microenvironment in Class 2 μm by regulating PROS1 (Kaler et al. 2022)."
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"Deletion of BAP1 in UMC026 cells and knockdown of BAP1 in Mel202 (class 1) cells resulted in upregulation of PROS1, whereas ectopic expression of BAP1 in BAP1-deficient MP46 (class 2) cells resulted in downregulation of PROS1 (Figure 1B and Supplementary Figures S1 and S2)."
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"These findings suggest that BAP1 represses PROS1 at least in part by epigenetic mechanisms, and that BAP1 loss leads to increased PROS1 expression."
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"However, it remains unknown how BAP1 mutations may mechanistically lead to immune suppression.As a potential explanation, we found here that BAP1 loss results in upregulation of PROS1 in UM cells through epigenetic mechanisms involving H3K27ac accumulation at the PROS1 locus, consistent with our previous findings [18]."
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