IndraLab

Statements

LFA_1 binds CALM1. 8 / 8
| 2 6
sparser
"Perhaps the interaction of LFA-1 with I-CAM delivers signals to the CTL which can act in an additive way with signals via the TcR/CD3 complex for optimal killing activity."
2577219
sparser
"Recent studies have shown that hepatic CD8 + Trm cells adhere to the liver via LFA-1, and the residence of CD8 + T cells in the hepatic sinusoid depends on the LFA-1-I/CAM-1 interaction ( xref )."
35096624
sparser
"The prevention of LFA-1 and CAM-1 interaction by lifitegrast presumably reduces further T-cell mediated inflammation [86] ."
30802601
reach
"Some of the bicyclic [5,5] hydantoin scaffold having fluorine and chlorine are found to be potent inhibitors of the LFA-1 and CAM interaction and farnesyl transferase [24]."
19014909
sparser
"Our investigations show no response to LFA-1/ICAM-1 alone, but that costimulation by LFA-1/CAM-1 interaction induces prolonged inositol phospholipid hydrolysis (up to 4 h), resulting in generation of both inositol(1,4,5)phosphate3 and inositol(1,3,4,5)phosphate4 and their derivatives."
1360995
reach
"The prevention of LFA-1 and CAM-1 interaction by lifitegrast presumably reduces further T-cell mediated inflammation [86] ."
30802601
sparser
"Stimulation of the CXCR2 receptor leads to the activation of the ß2-integrins LFA-1 and Mac-1, which interact with I-CAM on the surface of the endothelial cell leading to firm adhesion [5] ."
29929938
sparser
"A = lack of M H C classI antigen expression by tumour cells permitting escape from cytolytic T-cells; B=sheddingofI-CAM-1 into circulation may block T-cell receptors for this molecule and prevent tumour cell/cytolytic cell interactions; C=Tcells binding to classI antigen and D = stabilisation in association with I-CAM-1/LFA-1 interaction."
1376386