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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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USP16 activates cell differentiation. 5 / 5

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"When ESCs are differentiated, Usp16 is required to reverse ubH2A mediated gene repression and enables gene activation and subsequent ESC differentiation."

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"Usp16 regulates H2A deubiquitination and modulates self-renewal and differentiation in different types of cells."

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"Finally, Usp16, but not a catalytically inactive mutant, rescues the differentiation defects of Usp16 -/- ESCs."

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"Wild-type Usp16 rescues Usp16 -/- ESC differentiation defect."

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"Finally, we demonstrate that Usp16, but not the enzymatically inactive mutant, rescues the differentiation defects of Usp16 -/- ESCs."

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Statements

USP16 activates cell differentiation. 5 / 5

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