IndraLab

Statements

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"Wild-type Usp16 rescues Usp16 -/- ESC differentiation defect."
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"When ESCs are differentiated, Usp16 is required to reverse ubH2A mediated gene repression and enables gene activation and subsequent ESC differentiation."
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"Finally, Usp16, but not a catalytically inactive mutant, rescues the differentiation defects of Usp16 -/- ESCs."
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"Usp16 regulates H2A deubiquitination and modulates self-renewal and differentiation in different types of cells."
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"Finally, we demonstrate that Usp16, but not the enzymatically inactive mutant, rescues the differentiation defects of Usp16 -/- ESCs."
24784029