IndraLab

Statements

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"The fact that TREK-1 contributes to cell proliferation might in part explain our finding that TREK-1 expression was positively associated with GS and T staging."
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"XREF_BIBR In contrast, the knockdown of TREK-1 significantly inhibited the proliferation of prostate cancer cells."
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"TASK channels are expressed in lymphocytes, where they could contribute to inflammatory responses [55], and TASK-3 and TREK-1 are overexpressed in breast and prostate cancer cells, where they support cell proliferation and tumorigenesis [56,57]."
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"The two-pore domain K + channel, TREK1, increases proliferation of PC-3 and LNCaP prostate cancer cells."
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"The authors also found that TREK-1 blockers could inhibit cell proliferation of ovarian cancer cells through reducing early apoptosis and increasing late apoptosis."
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"Furthermore, TREK1 knockdown inhibited the proliferation of LX-2 cells."
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"For instance, some KCNK2 modulators inhibit apoptosis and promote proliferation in ovarian cancer [14]."
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"Furthermore, TREK-1 inhibits proliferation of neuronal stem cells, astrocytes, osteoblasts, Chinese hamster ovary cells, and neonatal cardiomyocytes, but increases the proliferation of prostate cancer cell lines."
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"Furthermore, knockdown of TREK-1 significantly inhibited PCa cell proliferation in vitro and in vivo, and induced a G1/S cell cycle arrest."
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"XREF_BIBR Overexpression of TREK-1 in healthy prostate epithelial cells increased their proliferation ability."
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"Taken together, our results demonstrated that TREK-1 knockdown inhibited cell proliferation of PCa cells."
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"In addition, TREK-1 knockdown significantly attenuated prostate cancer cell proliferation both in vitro and in vivo."
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"In both prostate [125] and ovarian cancer [220], the inhibition or knockdown of K 2.1 inhibits proliferation by inducing cell cycle arrest at the G /S checkpoint."
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