IndraLab

Statements

UCHL1 increases the amount of TP53. 3 / 4
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"Thus, in breast cancer models, UCHL1 can induce the levels of p53 and reduce mdm2 protein levels."
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"However, the specific manner in which UCH-L1 modulates p53 level and function remains controversial."
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"On the contrary, UCH-L1 elevates p53 levels in MDA-MB-231 and HONE1 cells, which express DNA binding domain mutant p53 with little to no transcriptional activity [XREF_BIBR - XREF_BIBR] and LNCaP cells, which have also been reported to express DNA binding domain mutant p53 [XREF_BIBR], although this is controversial [XREF_BIBR]."
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