IndraLab

Statements

Gallic acid inhibits RIPK1. 4 / 4
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"GA, an inhibitor of the heat shock protein 90 kDa (HSP90) XREF_BIBR, was known to downregulate the protein level of RIPK1 XREF_BIBR and therefore was expected to halt necroptosis."
22860037
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"Second, GA treatment causes degradation of RIP, resulting in the assembly of a TNF-R1 signaling complex lacking RIP and defective in IKK activation."
11864612
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"MG-132, a specific proteasome inhibitor, abrogated GA induced degradation of RIP but failed to restore the activation of IkappaB kinase by TNF, perhaps because, in the presence of GA and MG-132, RIP accumulated in a detergent-insoluble subcellular fraction."
10744744
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"Geldanamycin (GA), an antitumor of benzoquinone ansamycin (Stebbins et al., 1997), is an HSP-90 inhibitor and induces RIP degradation, followed by inhibition of NF-kappaB-mediated protection (Lewis et[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12493534