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"Geldanamycin (GA) was utilized to block the RIP1-mediated signaling cascade ( Holler et al., 2000 )."

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"In addition, treatment with GA reduced the over-expression of hall markers of necroptosis, including p-MLKL, p-RIPK1 and p-RIPK3, while upregulation of the protein levels of FADD, c-FLIP L and cleaved[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"GA, an inhibitor of the heat shock protein 90 kDa (HSP90) XREF_BIBR, was known to downregulate the protein level of RIPK1 XREF_BIBR and therefore was expected to halt necroptosis."