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SPP1 activates CD44. 40 / 54
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"Western blotting revealed that EEOS effectively attenuated the expression of OPN and CD44 and also OPN activated CD44 at nontoxic concentrations in NCI-H460 cells."
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"These studies indicate, therefore, that the level of cell surface CD44 is critical for GPCR mediated chemotaxis by peritoneal macrophages and suggest that a novel intracellular form of OPN may modulate CD44 activities involved in these processes."
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"Western blotting revealed that EEOS effectively attenuated the expression of OPN and CD44 and also OPN activated CD44 at nontoxic concentrations in NCI-H460 cells."
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"Osteopontin modulates CD44 dependent chemotaxis of peritoneal macrophages through G-protein-coupled receptors : evidence of a role for an intracellular form of osteopontin."
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"OPN has been known to bind and activate both integrin and CD44 [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
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"Because of the PVN localization of OPN and CD44, and CD44 being a marker of stem-like cells, we asked whether activation of CD44 by OPN could induce the stem-like phenotype."
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"Interestingly, the secreted OPN activated HCV replication, infectivity and assembly through binding to alphaVbeta3 and CD44."
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"OPN significantly increases HCV replication in EpCAM + / CD44 + CSCs."
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"Because of the PVN localization of OPN and CD44, and CD44 being a marker of stem like cells, we asked whether activation of CD44 by OPN could induce the stem like phenotype."
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"In this study, we found that osteopontin expressed by tumor cells enhances extramedullary myelopoiesis in a CD44 dependent manner through the Erk1/2-MAPK pathway."
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"Acting through integrin alpha (v) beta (3) and CD44 receptors, OPN can promote chemoattraction and pro inflammatory cytokine expression by macrophages."
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"Osteopontin increases hepatocellular carcinoma cell growth in a CD44 dependant manner."
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"OPN mediated CD44 engagement can prevent cell death by activation of the phosphatidylinositol 3-kinase/Akt signaling axis and by inhibition of Fas induced signals [XREF_BIBR, XREF_BIBR]."
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"OPN promotes survival of activated T cells by up-regulating CD44 in patients with oral lichen planus."
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"In a recent study, it was shown that osteopontin, possibly derived from astrocytes in the PVN, supports CD44 + glioma stem cells leading to enhanced tumor outgrowth and radiation resistance."
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"Both basal and +4 cardia stem cells express CD44, which are activated by a CD44 ligand, osteopontin (Fig. 5D) (Fu et al., 2020)."
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"siRNAs (ON-TARGETplus) targeting CD44 (L-009999-06), OPN (also referred as SPP1) (L-012558-09) and NT (Non targeting Pool) (D-001810-10-05) were purchased from Thermo Fisher Scientific and transfected with Lipofectamine RNAiMAX (Invitrogen) following the standard protocol."
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"These differential effects of OPN on cardiac myocyte apoptosis under different pathologies may include different neurohormonal response under diverse pathological conditions, cell-type/s involved in the expression of OPN, receptor/s (integrins or CD44) stimulated by OPN and/or differential post-translational modifications of OPN, including phosphorylation and glycosylation."
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"CD44 and OPN were found to colocalize in the perivascular niche (where stem-like glioma cells reside), so the question of whether OPN activated CD44 to cause a stem-like phenotype was asked."
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"Interestingly, splenic CD44 + T cell survival was not increased by the addition of osteopontin in vitro, which suggests that osteopontin may not affect all T cells expressing CD44."
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"These results indicated that OPN increases HCV replication in EpCAM + / CD44 + CSCs through the OPN-CD44 axis."
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"In line with this, exogenous HA application increased calcium deposition in pig bone marrow stromal cells [XREF_BIBR], and osteopontin expression was enhanced during bone formation in mouse [XREF_BIBR], indicating the possible involvement of CD44 in bone development."
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"OPN, as the main organic component of the stone matrix, promotes the adhesion of CaOx crystals to surface of tubular cells via binding to its receptor CD44 (30)."
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"Furthermore, expression of OPN promotes macrophage activation viabinding of CD44, induces a scavenger function and acts against acute tissue destruction."
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"For example, osteopontin induces CD44 dependent chemotaxis and down-modulates anti-inflammatory IL-10 secretion through interactions with CD44, and is hypothesized as an activator of the CD44 variant survival signal in lymphocytes by the extracellular matrix of the gut mucosa Intriguingly, CD44v7, a principal CD44 isoform sufficient for osteopontin binding, is the isoform present in our Gottron 's papules."
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"OPN mediated increase of MMP-9 and CD44 in prostate cancer cells paired with the fact that highly tumorigenic cells often overexpress OPN provides insight to the observed increase in motility and invasiveness of metastatic cells."
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"5 nM OPN increases CD44 protein half-life from 105 +/- 11 minutes to 278 +/- 15 minutes."
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"Our results suggested that the abnormally elevated levels of OPN may contribute to the abnormal infiltration and accumulation of the activated T cells by up-regulating CD44 in OLP."
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"Our observations suggest that OPN/SPP1 could promote stemness signature in PC cells by regulating the CD44-mediated stem cell markers NANOG, KLF4, BMI-1, and ABCG2."
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"In summary, EEOS significantly inhibited cell adhesion and invasion at nontoxic concentrations, attenuated the expression of OPN and CD44 and also OPN activated CD44 in NCI-H460 cells."
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"We have previously demonstrated that osteopontin mediated engagement of CD44 spliced variant isoforms promotes an extracellular matrix derived survival signal through integrin activation."
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"Osteopontin, which is derived from the perivascular niche, promotes GSCs phenotype by activating CD44, one of the CSC markers."
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"Regarding the mechanisms involved, OPN activates CD44 and integrins in a para- or autocrine manner and induces PI3K/Akt and mitogen-activated protein kinase (MAPK) signaling ( xref )."
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"In addition, OPN selectively induces CD44 dependent chemotaxis, the latter of which contributes to tumor cell migration and invasion."
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"OPN promotes CD44-mediated effects on SCJ epithelium."
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"Therefore, we investigated whether OPN triggers AKT activity in neurospheres derived from GBM30 and GBM1600 (both CD44 high), as well as GBM157 (CD44 low) (XREF_FIG, upper left panel)."
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"Additionally, OPN induced radiation resistance by activating the CD44 signaling pathway in glioma [58]."
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"Previous studies found that OPN modulates cell migration, EMT, ECM-invasion and stemness maintaining of tumor cell via binding integrins and CD44 or activating NF-Kb, MEK and MAPK, PI3K and Akt, and FAK pathways XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR."
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"In summary, EEOS significantly inhibited cell adhesion and invasion at nontoxic concentrations, attenuated the expression of OPN and CD44 and also OPN activated CD44 in NCI-H460 cells."
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"It has been reported, that through binding to cell surface receptor CD44, perivascular niche-derived OPN promotes the stemness and tumorigenicity of cancer cells via cleavage and translocation of the C-terminal intracellular domain (ICD) of CD44 into the nucleus ."
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