IndraLab

Statements

VCPIP1 increases the amount of cccDNA. 2 / 2
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"Moreover, VCPIP1 recruited PSMC3, promoting HBx protein levels, and enhanced HBV cccDNA transcription."
35695579
reach
"In this study, we demonstrated that VCPIP1 recruiting PSMC3 promoted the HBV cccDNA transcription by inhibiting HBx degradation, which suggested that drugs or methods targeting VCPIP1 and PSMC3 may produce better efficacy to antagonize HBV cccDNA.In summary, VCPIP1 is a novel DUB that stabilizes HBx in a ubiquitin-independent manner, serving as a scaffold for the interaction between free proteasome subunits PSMC3 and HBx."
35695579