IndraLab

Statements


USP4 increases the amount of VIM. 2 / 2
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"Importantly, depressed expression of USP4 inhibited TβRI expression and partially reversed EMT stimulated by TGF-β1.In the meantime, blunted phosphorylation of Akt promoted the E-cadherin expression, and inhibited α-SMA and Vimentin expression in response to TGF-β1."

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"Results showed that inhibition of USP4 and Smurf2 expression significantly reverses the altered expression of ZO-1, Vimentin and TbetaRI induced by TGF-beta1, while overexpression of Akt augments these effects."