IndraLab

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BmKKx2 inhibits KCNH2. 3 / 3
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"When scorpion toxin BmKKx2 reduced the proliferation of K562 cells, it was beneficial to investigate whether BmKKx2 would enhance erythroid differentiation of K562 cells by inhibiting the hERG potassium channel."
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"As shown in Figure XREF_FIG A, BmKKx2 could effectively block hERG channel with an IC 50 of 6.7 +/-1.7 nM, which was comparable to that of BeKm-1, an effective blocker of hERG channel [XREF_BIBR]."
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"BmKKx2 was found to block hERG channel with an IC 50 of 6.7 +/-1.7 nM and share similar functional surface with the known hERG channel inhibitor BeKm-1."
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