IndraLab

Statements

USP10 activates MSH2. 3 / 3
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"31 In recent years, it has been shown that USP10 mediates the stabilization of MSH2 and reverses the resistance to DNA-methylating agents and antimetabolites in cancer cells ( Fig. 1 )."
35760282
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"So, HDAC6 and USP10 exert opposing effect on MSH2 : HDAC6 promotes degradation of MSH2, while USP10 promotes stabilization of MSH2."
32382008
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"However, it seems to contradict the finding that USP10 promotes sensitivity to 6-TG by stabilizing MSH2 41."
32382008