IndraLab

Statements

reach
"A luciferase reporter assay performed in BMMs suggested that USP7 inhibition promoted NF-κB and Nfatc1 transcription activities, which are critical for osteoclast differentiation (Supplementary Fig. 6)."
37199589
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"USP7 depletion-mediated destabilization of RUNX3 leads to decreased Sα transcription, allowing loop extrusion to the upstream Sγ regions to activate their transcription by aligning them with the CSRC [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38735043
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"In addition, USP7 inhibition enhances transcription activation of GCs target genes, such as BCL2L11 and TSC22D3, through increasing the promoter and intronic GR-binding region (IGR) connectivity."
36490346
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"Meanwhile, the wrong position of USP7 would also disrupt its transcription regulation function in acute promyelocytic leukaemia in a metabolic energy dependent manner [ 38 ]."
32092586
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"USP7 also inhibits FoxO1-dependent transcription by removing monoubiquitin from FoxO1 [101]."
36834633
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"Knockdown of USP7 expression consistently reduced the expression levels of signal transducer and activator of transcription (STAT)-1, STAT-2 and selected IFN inducible genes, including IFN induced protein with tetratricopeptide repeats 3, MX dynamin like GTPase 1 and 2 '-5'-oligoadenylate synthetase 1."
28656291