IndraLab

Statements

BAP1 inhibits DNA repair. 5 / 5
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"Specifically, BAP1 suppresses genome instability via its DNA repair activity and eliminates cancer-prone cells that exhibit genome instability by promoting apoptosis."
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"The powerful activity of heterozygous germline BAP1 mutations to facilitate asbestos induced transformation and cause mesothelioma has been linked to the alterations in the mechanisms that regulate DNA repair and cell death caused by decreased BAP1 protein levels."
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"Functional studies were not conducted because cells from these patients were not available.Our findings revealed that both BAP1 and BARD1 inactivate similar pathways: DNA repair, calcium signaling, and cell death, although through different mechanisms."
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"Defects in BAP1 disrupt DNA replication, DNA repair, calcium homeostasis, cell proliferation and differentiation, and cell metabolism [34]."
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"BAP-1 deficiency causes damage to DNA as well as defects in the DNA repair mechanism [103]."
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