IndraLab

Statements

KCNA1 binds KCN. 5 / 5
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"Voltage‐gated Kv1.1 potassium channel α‐subunits, which are associated with sudden unexpected death in epilepsy (SUDEP) in mice, have recently come to light as important regulators of cardiac repolarization and arrhythmia susceptibility in atria (Glasscock et al., xref ; Si et al., xref )."
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"According to earlier investigations, the voltage-dependent potassium channel formed by Kv1.1 and Kvb1.1 subunits produces a current characterized by fast-inactivating and sustained components."
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"Next, we wanted to determine whether Kv1.1 protein could form functional potassium channels in the Fezf2-GFP-positive cells."
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"Mutations in KCN1A, the gene encoding Kv1.1, a voltage-gated neuronal potassium channel, are associated with the disorder."
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"Browne D, Gancher S, Nutt J, Brunt E, Smith E, Kramer P, Litt M: Episodic ataxia/myokymia syndrome is associated with point mutations in the human potassium channel gene, KCNA1."
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