IndraLab

Statements


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sparser
"Next, we examined whether USP18 directly interacts with NEMO."

reach
"To further confirm endogenous interaction between USP18 and NEMO, we stimulated THP-1 derived macrophages with LPS for various time points."

reach
"Little binding between USP18 and NEMO or between USP18 and IKKbeta was observed in unstimulated cells."

No evidence text available

No evidence text available

reach
"Next, we examined whether USP18 directly interacts with NEMO."

sparser
"Mutation analysis revealed direct binding of USP18 to the UBAN motif of NEMO."

sparser
"Co-immunoprecipitation experiments showed that USP18 only interacted with full length (FL) NEMO or its UBAN domain ( xref )."

sparser
"To further confirm endogenous interaction between USP18 and NEMO, we stimulated THP-1 derived macrophages with LPS for various time points."