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USP1 activates protein deubiquitination. 2 / 2

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"Ubiquitin-specific peptidase 1 (USP1) reportedly promotes tumorigenesis in various cancers, including breast cancer[20] and myeloma[21], by regulating protein deubiquitination."

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"Collectively , we showed that USP1 interacts with KDM4A and promotes its deubiquitination , ultimately leading to KDM4A stabilization , and inhibition of USP1 promotes the response of PC cells to therapeutic agent enzalutamide ( Figure7H ) ."

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USP1 activates protein deubiquitination. 2 / 2

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