IndraLab

Statements

OTULIN activates cell death. 9 / 9
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"These OTULIN-deficient cells are also sensitized to TNF-induced cell death ."
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"OTULIN overexpression or knockdown affects NF-kappaB responses to LUBAC, TNFalpha, and poly (I : C) and sensitizes cells to TNFalpha induced cell death."
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"This scenario was later confirmed by reports showing that OTULIN deletion in the liver causes TNFR1-driven, apoptosis- and compensatory proliferation-mediated liver pathology, while OTULIN deletion in keratinocytes causes TNFR1-driven, RIPK1 kinase activity-mediated, cell death-dependent skin inflammation [65,66] (Table 1)."
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"The recently identified linear-chain-specific DUB OTULIN has been implicated in the regulation of TNF induced NF-kappaB activation and cell death XREF_BIBR."
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"One could speculate that absence of OTULIN activity can induce cell death only in some cell types, while in others sustained NF-κB activation would be the main outcome."
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"Finally, in line with the role of OTULIN in preventing LUBAC autoubiquitination and degradation [ 41 ], OTULIN-deficient skin fibroblasts from patients with ORAS show reduced expression of HOIP and SH[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Surprisingly, overexpression of wild-type OTULIN abrogates the RIPK1-NEMO interaction and sensitizes to TNFalpha induced cell death, as well [XREF_BIBR]."
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"Moreover, stable overexpression of OTULIN sensitized cells to TNFalpha induced cell death (XREF_FIG D and 6E), consistent with observations in cpdm mice that lack Sharpin or in humans with mutations in HOIL1."
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"OTULIN deficiency sensitises fibroblasts and monocytes to TNF induced cell death."
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