IndraLab

Statements

OTULIN activates cell death. 6 / 6
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"OTULIN overexpression or knockdown affects NF-kappaB responses to LUBAC, TNFalpha, and poly (I : C) and sensitizes cells to TNFalpha induced cell death."
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"The recently identified linear-chain-specific DUB OTULIN has been implicated in the regulation of TNF induced NF-kappaB activation and cell death XREF_BIBR."
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"During necroptosis, OTULIN is hyper-phosphorylated at Tyr 56, which modulates RIPK1 ubiquitin dynamics and promotes cell death."
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"Moreover, stable overexpression of OTULIN sensitized cells to TNFalpha induced cell death (XREF_FIG D and 6E), consistent with observations in cpdm mice that lack Sharpin or in humans with mutations in HOIL1."
23746843
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"OTULIN deficiency sensitises fibroblasts and monocytes to TNF induced cell death."
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"Surprisingly, overexpression of wild-type OTULIN abrogates the RIPK1-NEMO interaction and sensitizes to TNFalpha induced cell death, as well [XREF_BIBR]."
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