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"Also, it was found that higher doses of HCQ when used in combination with other drugs, such as the antibiotic azithromycin, increased the risk of side effects [15,[17], [18], [19], [20]].8.2 Chloroquine and COVID-19."
| PMC
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"Administration of chloroquine and hydroxychloroquine combined with azithromycin or lopinavir and ritonavir can elevate plasma levels of chloroquine and further increase the risk of acute arrhythmias [XREF_BIBR]."
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"Of these, ten patients (5.0%) received chloroquine, 191 (95.0%) were treated with hydroxychloroquine and 119 (59.2%) also received azithromycin."
| PMC
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"In addition, HCQ has fewer concerns about drug-drug interactions and better safety profile and allows higher daily dose in comparison to chloroquine, leading us to think HCQ may act as a promising drug for the treatment of COVID-19 (Marmor et al. 2016; Yao et al. 2020)."
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"Chronic use of chloroquine or hydroxychloroquine for prevention of malaria or treatment of autoimmune diseases, can cause development of chloroquine retinopathy, a macular atrophy eventually disturbin[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Hydroxychloroquine 10 μM produced an average APD90 prolongation to 119.2 ± 82.6% of control values.3.7 Estimation of proarrhythmogenic risk predictors B net and Q net for chloroquine and hydroxychloroquine."
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"We also found heterogeneity among antimalarial agents, in that patients treated with chloroquine did better than those treated with hydroxychloroquine."
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