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OTUB1 activates YAP1. 7 / 7
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"OTUB1 was found to interact with YAP and subsequently inhibit YAP degradation."
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"The protein half-life assay showed that OTUB1 depletion impaired the YAP protein stability in gastric cancer cells (Fig. 5A, B)."
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"These findings suggest that OTUB1 might modulate YAP1 protein levels through its involvement in the ubiquitin‐proteasome pathway, thus regulating YAP1 stability.To advance our understanding of the role of YAP1 in the phenotypes driven by OTUB1 in HNSCC cells, we assessed the efficacy of YAP1 siRNA in mitigating the cell proliferation and invasion prompted."
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"Immunofluorescence analysis revealed that nuclear YAP1‐positive cells were significantly increased by OTUB1 overexpression (Figure 3E)."
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"Our present findings propose that OTUB1 may synergistically activate YAP1 with FAT1 gene alterations in HNSCC."
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"Our present findings propose that OTUB1 may synergistically activate YAP1 with FAT1 gene alterations in HNSCC."
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"Since OTUB1 modulates Hippo/YAP axis and gastric cancer progression, we further investigated the potential mechanism."
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