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Calcium(2+) inhibits KCNH2. 12 / 12
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"Ca 2+ Slows the Rate of HERG Channel Activation."
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"Besides, riluzole is known to act on several ion channels, such as activating K Ca 1.1, K Ca 2.3, and K Ca 3.1, and blocking hERG1 ion channels [ 25 ]."
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"Furthermore, we found that Ca 2+ greatly reduces the pH sensitivity of Kv11.1, or hErg1."
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"Elevated Ca 2+ decreased the rate of HERG activation at all potentials measured (+60 to 0 mV)."
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"Increasing extracellular Ca 2+ slowed the rate of HERG activation and accelerated deactivation (Figs."
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"In a later study, the sarcoplasmic/endoplasmic reticulum Ca 2+ -ATPase inhibitor thapsigargin was also found to rescue two trafficking defective hERG mutants, G601S and F805C, also without causing hER[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Ca 2+ Decreases HERG Current Amplitude and Shifts the Isochronal Activation Curve."
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"We found that trichloromethane cardiac toxicity was related to inhibition of multiple ionic currents, including L-type Ca 2+ current ( I Ca.L ), transient outward K + current ( I to ), voltage-gated s[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The explanation of a mitigated hERG channel blocking effect by Ca 2+ antagonism may not be considered entirely satisfactory, since bepridil, another Ca 2+ antagonist, also potently blocks the hERG cha[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"XREF_FIG and XREF_FIG also demonstrate that Ca 2+ does not block HERG directly."
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"Therefore, using confocal Ca imaging of single myocytes, we investigated whether blocking I has a major impact on Ca handling in LQT2 rabbits, thereby suppressing EADs in LQT2 hearts."
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"This seems quite likely, since hERG has been reported to be blocked by extracellular Ca 2+ ( Nguyen et al., 2015 )."
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