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BAP1 activates ferroptosis. 37 / 37
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"Consequently, BAP1-mediated downregulation of SLC7A11 leads to elevated lipid peroxidation and ferroptosis [88]."
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"Interestingly, solute carrier family 7 member 11 (SLC7A11) is a crucial regulated protein of ferroptosis, which has been reported as the target gene of BAP1.10 33 Therefore, we further verified the mechanism of BAP1 and SLC7A11 in H/R-induced cardiomyocyte ferroptosis."
39391723
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"BAP1, as a tumor suppressor, promotes ferroptosis and inhibits cancer cell growth by inhibiting SLC7A11 [94]."
37299036
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"It has been recently reported that BAP1 facilitates lipid peroxidation and promotes ferroptosis through repressing SLC7A11 [24]."
34732689
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"For example, p53 and BRCA1-related protein 1 (BAP1) induce ferroptosis in tumor cells through multiple signaling pathways, which act as a natural barrier to cancer development (5, 6)."
38125948
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"BAP1 induced mPTP opening reverses the inhibiting role of BMSC-derived Exos oe-GATA-4 on H/R-induced cardiomyocytes ferroptosis by interacting with IP3R."
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"BAP1 can promote ferroptosis and suppress tumor tumorigenesis [39]."
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"BAP1 can induce ferroptosis in a similar process to TP53 by downregulating SLC7A11 [57]."
37822917
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"Moreover, another study suggested that BAP1 upregulation is essential for ferroptosis induced by 3,3′-diindolylmethane in BGC-823 cells, suggesting that BAP1-induced ferroptosis could be one of the potential mechanisms by which it suppresses GC progression [113]."
36497313
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"These results suggested that BAP1 can mediate SLC7A11 inhibition and neuronal ferroptosis by regulating H2Aub.3.3 FOXO3a regulated BAP1 expression at the transcriptional level."
40080966
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"The FTO/BAP1 axis promoted MPP + -induced ferroptosis by suppressing SLC7A11."
39846440
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"ACSL4, LPCAT3, YAP1, HIF-2α, TP53, BAP1, IFNG, and HOMOX1 and the TCA cycle, hypoxia, reactive oxygen signaling pathway and glutathione metabolism signaling pathways have been proven to promote the occurrence of ferroptosis."
36518303
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"These results are intriguing and suggest that, although BAP1 is a multimeric complex with several activities involved in its recruitment and control of its activity, some associated partners might impose another layer of regulation on BAP1-mediated ferroptosis."
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"These results indicated that FOXO3a was activated in hemin-treated HT22 cells, and silencing FOXO3a effectively inhibited the expression of BAP1 and increased the expression level of SLC7A11.3.5 Overexpressed FOXO3a aggravated neuronal ferroptosis after treatment with hemin."
40080966
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"Previous reports, including ours, have demonstrated that BAP1 could promote apoptosis and ferroptosis to inhibit tumor development."
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"These authors found that the xc antiporter is a target of BRCA1-associated protein 1 (BAP1) and that BAP1 promotes ferroptosis through repressing xc antiporter expression, resulting in tumor suppression (Zhang et al., 2018)."
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"SLC7A11, a target gene downstream of BAP1, accelerates ferroptosis by diminishing SLC7A11 expression via a deubiquitination mechanism 168."
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"Inhibiting BAP1 can significantly reduce the level of lipid peroxidation and ferroptosis in neurons, and alleviate neurological deficits, brain edema and lipid peroxidation in SAH mice."
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"9 In addition, BRCA1-associated protein 1 (BAP1) triggers ferroptosis in the same way as TP53; thus, the antitumor activity is even more pronounced than that of non-ferroptosis-related tumor suppresso[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37682704
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"Studies have reported that BAP1 could promote ferroptosis by blocking the expression of SLC7A11 ."
34370716
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"Our results indicated that BAP1 induces ferroptosis in LPS-treated H9C2 cells."
38816686
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"In addition to TFs, SLC7A11 transcription is also repressed by BRCA1-associated protein 1 (BAP1) – a major component of a deubiquitinase (DUB) complex which catalyzes deubiquitination of histone 2 A (H2A) associated with the SLC7A11 promoter.96 Not surprisingly, BAP1 promotes ferroptosis in a DUB-dependent manner."
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"When SLC7A11 is inhibited, BAP1 triggers ferroptosis to partially inhibit cancer progression [23]."
37210575
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"p53 and BRCA1 Associated Protein 1 (BAP1) inhibit carcinogenesis in part by antagonizing SLC7A11 and induce ferroptosis (Zhang Y. et al., 2019)."
36467032
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"In addition, BRCA1-associated protein 1 (BAP1) also promotes ferroptosis by SLC7A11 downregulation [81]."
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"OTUB1 overexpression is frequently found in various human cancers, which maintains high expression of SLC7A11 in cancer cells by posttranslational regulation of OTUB1.De-repression of SLC7A11 also promotes tumor development partly via inhibiting ferroptosis, e.g., genetic mutations or deletions of tumor suppressor p53 or BAP1."
36552652
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"It was reported that the BRCA1-associated protein 1 (BAP1) tumor suppressor is also able to promote ferroptosis by repressing SLC7A11 [41]."
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"Unlike other tumour suppressors (e.g., p53, BAP1, KEAP1 and ARF (p14), which promote ferroptosis; see Box 2), this tumour-suppressive axis suppresses ferroptosis ."
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"A recent study found that BAP1 acts as an epigenetic regulator to promote ferroptosis through the downregulation of SLC7A11 expression in a de-ubiquitination-dependent manner [ 100 ]."
30880243
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"These authors found that the xc antiporter is a target of BRCA1-associated protein 1 (BAP1) and that BAP1 promotes ferroptosis through repressing xc antiporter expression, resulting in tumor suppression Zhang et al. (2018)."
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"Tumor suppressors such as NF2 suppress ferroptosis, whereas other suppressors such as MLL4 FBW7, and BAP1 promote ferroptosis [54]."
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"m6A Demethylase FTO-Mediated Upregulation of BAP1 Induces Neuronal Ferroptosis via the p53/SLC7A11 Axis in the MPP+/MPTP-Induced Parkinson's Disease Model."
39846440
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"It was reported that the BRCA1-associated protein 1 ( BAP1 ) tumor suppressor is also able to promote ferroptosis by repressing SLC7A11 [ 41 ] ."
32413317
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"We further explored the effect of BAP1 in H/R-induced cardiomyocyte ferroptosis and found that the cell viability was decreased in cardiomyocytes with the Exos +miR-330-3p inhibitor."
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"It has been reported that BRCA1-associated protein 1, another tumor suppressor, induces ferroptosis by repressing SLC7A11 in a similar way to p53 (Zhang et al., 2018)."
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"BAP1 induced ferroptosis by inhibiting SLC7A11."
38816686
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"Several tumor-suppressors, such as p53 [69] , BAP1 [70] , and KEAP1 [71] , promote ferroptosis through inactivating SLC7A11, while some oncogenic signaling pathways such as PI3K-mTORC1 pathway have be[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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