IndraLab

Statements

USP18 increases the amount of ZEB1. 3 / 3
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"As shown in Fig. 4 E, knockdown of USP18 decreased ZEB1 expression, whereas the upregulation of ZEB1 attenuated the loss of ZEB1 expression in TE10/shUSP18 cells."
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"Indeed, knockdown of USP18 significantly suppressed the expression of ZEB1, as well as the EMT process and metabolic phenotype of ESCC cells."
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"Finally, our results revealed that USP18 knockdown obviously reduced the ubiquitination level of ZEB1 in ESCC cells ( Fig. 5 F)."
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