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USP4 deubiquitinates TWIST1. 2 / 3
1 | 2

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"Moreover, TWIST1 is deubiquitinated by USP4 in NSCLC cells, resulting in an increased stemness of NSCLC cells [18]."

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"We have previously shown that USP4 can deubiquitinate and stabilize Twist1 protein [23], so we then asked whether USP4 is involved in FBXO3-induced Twist1 stabilization."