IndraLab

Statements

BAP1 is methylated. 28 / 28
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"Therefore, we investigated whether BAP1 body methylation may influence BAP1 gene expression."
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"Aberrant methylation of BAP1 and SF3B1 is thought to be associated with UM metastasis ( xref )."
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"Recently, also BAP1 methylation has been recognized as an important prognostic marker of UM metastasis."
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"In the bone, skin, and liver, UM metastasis was found to be caused by aberrant methylation of BAP1 and SF3B1 ."
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"However, despite this lack of effect, differences in BAP1 methylation between the MP41 and MP46 cell lines suggest that BAP1 expression may indeed be regulated by DNA methylation."
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"Using The Cancer Genome Atlas (TCGA) database we analyzed BAP1 methylation in several tumor types, at nineteen sites spanning the entire BAP1 promoter, gene and 3′ untranslated region ( xref )."
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"Similarly, no BAP1 methylation alterations were found in clear cell renal carcinoma xref ."
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"We investigated BAP1 promotor methylation as a potential mechanism for epigenetic inactivation in 19 subjects with sufficient tumor and non-tumor tissues including the proband 7002 with downregulation of BAP1 in non-tumor choroid."
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"Pyrosequencing showed no significant BAP1 promotor methylation in any of the 19 studied subjects including the subject with significant constitutional downregulation of BAP1 in the non-tumor tissue."
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"BAP1 methylation has been recognized as a significant prognostic indicator for metastasis in UM."
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"Aberrant methylation of BAP1 and SF3B1 was discovered to be the cause of UM metastases in the bone, skin, and liver."
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"We analyzed the status of BAP1 promoter methylation because we did not find BAP1 coding mutations in MP46 xref despite the absence of BAP1 protein."
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"Inactivation of BAP1 expression by BAP1 methylation, as has been observed in some uveal melanoma cases, could also be a contributing factor ( xref , xref )."
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"Higher levels of BAP1 promoter methylation are linked to poorer clinical outcomes ( xref )."
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"MEXPRESS was used to verify the BAP1 gene DNA methylation in UVM cases ( Koch et al., 20192019; Koch et al., 2015 )."
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"A significantly negative correlation was observed between BAP1 expression and BAP1 DNA methylation at the promoter region, such as cg24291822 ( p < 0.001, r = -0.485), suggesting that BAP1 expression [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"TCGA data analysis tool, UALCAN, was used to explore BAP1 DNA methylation in various cancers."
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"There are also no reports that review the methylation of BAP1 in ICC or GBC."
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"Results showed that there were statistically significant differences in methylation of BAP1 in bladder urothelial carcinoma (BLCA), colon adenocarcinoma (COAD), ESCA, HNSC, KIRC, kidney renal papillar[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In this study, results revealed that there was a statistically significant association between high expression of BAP1 and reduced BAP1 methylation level at the promoter region in UVM cases, indicatin[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"By analyzing 22 sporadic MM biopsies, Nasu and colleagues found that BAP1 promoter methylation was not altered in MM ( xref )."
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"To determine whether the low BAP1 mRNA levels in class 2 tumors without detectable BAP1 mutations may be explained by DNA methyation, we performed a preliminary analysis of DNA methylation of BAP1."
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"BAP1 promoter and body Methylation are not altered in Malignant Mesothelioma."
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"Robertson et al. identified four distinct UM subtypes based on the status of chromosome 3 and BAP1 methylation: two groups associated with poor prognosis characterized by monosomy 3, and two groups with a better prognosis characterized by disomy 3."
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"According to a study by Bakhoum, the levels of BAP1 protein, BAP1 mutations, and BAP1 genomic copy loss are all correlated with the methylation of BAP1 at a single genomic locus."
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"The methylation of BAP1 at a particular genomic locus is connected to BAP1 protein levels, BAP1 mutations, and BAP1 genomic copy loss, according to a study by Bakhoum [ xref , xref ]."
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"Our analysis of epigenetic alterations revealed some associations between BAP1 status and DNA methylation ( xref )."
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"Robertson et al. identified four different UM subtypes, based on chromosome 3 status and BAP1 methylation: two groups with bad prognosis and with monosomy 3 and two with better prognosis and with disomy 3."
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