IndraLab

Statements

reach
"Secretion of SLO and its co-toxin NADase from adherent bacteria increases the local concentration of both toxins and markedly increases the efficiency of SLO-mediated translocation of NADase into host cells (7)."
39835825
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"These and subsequent studies provided evidence that SLO mediated delivery of NADase augmented the cytotoxic effect of SLO and induced epithelial cell apoptosis [XREF_BIBR, XREF_BIBR]."
26938870
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"Thereby, streptolysin O (SLO) mediates the internalization of S. pyogenes NAD-glycohydrolase, which contributes to the cytotoxicity and to the induction of inflammatory response [71]."
38668607
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"Whereas NADase delivery to epithelial cells is mediated by SLO secreted from GAS bound to the cell surface, in macrophages, the source of SLO and NADase is GAS contained within phagolysosomes."
25227466