IndraLab

Statements

reach
"JOSD1 has been identified to negatively regulate IFN-I-induced signaling and the antiviral response by deubiquitinating the K48-linked polyubiquitination of SOCS1, which is an essential negative regulator of many cytokine signaling pathways (120)."
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reach
"JOSD1 can inhibit the IFN-1-induced signalling pathway and antiviral response by physically interacting with SOCS1 and enhancing SOCS1 stability by cleaving K48-ubiquitin chains from SOCS1 [21]."
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