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USP10 inhibits cell death. 16 / 16
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"To obtain information describing how USP10 inhibits MG-132-induced cell death, we measured cell death of USP10-KD cells expressing several USP10 mutants."
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"Overexpression of USP10 abrogated Wu-5-induced FLT3-ITD degradation and cell death."
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"Thus, we examined whether USP10 inhibits MG-132-induced cell death by measuring activated caspase-3 (cleaved caspase-3)."
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"To determine which USP10 function inhibits cell death after cytokine starvation, we examined three USP10 mutants (XREF_FIG G)."
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"Moreover, we examined cellular viability and found that overexpression of PPM1B promoted cell death, knockout of PPM1B inhibited cell death, while USP10 suppressed cell death."
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"USP10 Inhibits Cell Death Induced by MG-132."
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"These results indicated that USP10 and p62 cooperatively inhibit MG-132-induced cell death by promoting the formation of aggresomes and p62 aggregates."
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"To obtain information describing how USP10 inhibits MG-132-induced cell death, we measured cell death of USP10-KD cells expressing several USP10 mutants."
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"USP10 C424A and USP10 96-798, but not USP10 1-214, reduced cell death of USP10-KD cells (XREF_FIG G and XREF_SUPPLEMENTARY A-S5C)."
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"Given that USP10-WT, USP10 C424A, and USP10 96-798, but not USP10 1-214, in USP10-KD cells promoted p62 aggregation and aggresome formation (XREF_FIG G and XREF_SUPPLEMENTARY A-S5C), these results suggested that USP10 inhibits cell death induced by MG-132 by promoting aggresome formation and p62 aggregation."
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"USP10 inhibited cell death induced by PI, and the inhibition correlated with aggresome/aggregate-inducing activity ( xref and xref )."
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"USP10 inhibited cell death induced by PI, and the inhibition correlated with aggresome and aggregate inducing activity (XREF_FIG and XREF_SUPPLEMENTARY)."
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"Thus, we examined whether USP10 inhibits MG-132-induced cell death by measuring activated caspase-3 (cleaved caspase-3)."
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"These results indicated that USP10 and p62 cooperatively inhibit MG-132-induced cell death by promoting the formation of aggresomes and p62 aggregates."
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"Similar to Beclin 1 knockdown, we found that suppression of the ubiquitin specific peptidase, USP10, or a small molecule inhibitor of the deubiquitinases USP10 and USP13, i.e., spautin-1 XREF_BIBR, can increase radiation induced DSBs and promote tumor cell death."
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"Given that USP10-WT, USP10 C424A , and USP10 96−798 , but not USP10 1−214 , in USP10-KD cells promoted p62 aggregation and aggresome formation ( xref G and xref A–S5C), these results suggested that USP10 inhibits cell death induced by MG-132 by promoting aggresome formation and p62 aggregation."
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