IndraLab

Statements

reach
"We found that the hERG blocker E-4031 decreased proliferation as assayed by sphere formation in a GPDC line exhibiting high levels of hERG expression, whereas blocking hERG in low hERG expressing lines does not decrease proliferation to the same extent."
27635088
reach
"Application of the hERG1 activator, the diphenylurea derivative NS1643, inhibits cell proliferation irreversibly."
23744352
reach
"Knockdown of hERG1 significantly suppressed cellular proliferation and invasion, and induced apoptosis, while inhibition of hERG1 significantly decreased activation of NF-kappaB."
27076857
reach
"In addition, leukemic cell proliferation was dramatically inhibited by HERG K+ channel special inhibitor E-4031."
17641836
reach
"XREF_FIG - XREF_FIG, hERG1 downregulation and/or inhibition prevented proliferation and invasion, and induced apoptosis of osteosarcoma cells."
27076857
reach
"Furthermore, HERG small interfering (si) RNA attenuated the proliferation and migration of the cells."
19765650
reach
"Therefore, Kv11.1 inhibits TNBC cell proliferation by activating a cellular senescence program [98]."
32782435
reach
"Altogether, these results suggest that the hERG1 agonist NS1643 inhibits proliferation of SKBr3 cells by downregulating the expression of a plethora of important cell cycle phase specific biomarkers including an early decrease of cyclin E2."
23744352
reach
"[Downregulation of Herg1 suppresses osteosarcoma proliferation and invasion by targeting Hippo signaling pathway]."
31137166
reach
"Increased hERG1b levels are expected to depolarize cells, while high hERG1 levels will shift membrane potential toward more hyperpolarized values 35 and suppress cell proliferation."
21850047
reach
"For example, the HERG channels are associated with cell cycle and proliferation of several cancers; therefore, the use of HERG specific blockers could inhibit the proliferation of tumor cells [XREF_BIBR]."
26273285
reach
"Reduced expression of the hERG protein by siRNA transfection resulted in decreased cell proliferation in small cell lung cancer cells [XREF_BIBR], and a hERG channel promoted the proliferation of ovarian cancer cells by affecting the cell cycle [XREF_BIBR]."
24434641
reach
"To further evaluate whether silencing herg gene in SH-SY5Y cells may inhibit cell growth and proliferation, the growth curves of cells nontransfected and transfected with shRNA-herg1, shRNA-herg1/1b o[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17976575
reach
"HERG potassium channel blockers modulate proliferation."
21850047