IndraLab

Statements

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"[Downregulation of Herg1 suppresses osteosarcoma proliferation and invasion by targeting Hippo signaling pathway]."
31137166
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"HERG antagonists block the HERG channel, inhibit the proliferation and migration of cancerous cells, and inhibit the potassium channel of myocardial cells, resulting in severe arrhythmia (58,59)."
34737803
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"For example, the HERG channels are associated with cell cycle and proliferation of several cancers; therefore, the use of HERG specific blockers could inhibit the proliferation of tumor cells [XREF_BIBR]."
26273285
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"Altogether, these results suggest that the hERG1 agonist NS1643 inhibits proliferation of SKBr3 cells by downregulating the expression of a plethora of important cell cycle phase specific biomarkers including an early decrease of cyclin E2."
23744352
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"HERG potassium channel blockers modulate proliferation."
21850047
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"XREF_FIG - XREF_FIG, hERG1 downregulation and/or inhibition prevented proliferation and invasion, and induced apoptosis of osteosarcoma cells."
27076857
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"We identified two novel hERG activators, SDUY429 and SDUY436 , which effectively inhibited the proliferation and migration of MDA-MB-231 and MCF-7 cells."
39917621
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"Application of the hERG1 activator, the diphenylurea derivative NS1643, inhibits cell proliferation irreversibly."
23744352
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"Therefore, Kv11.1 inhibits TNBC cell proliferation by activating a cellular senescence program [98]."
32782435
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"In addition, E4031, a hERG1 blocker, can reduce the proliferation of leukemia, gastric and neuroblastoma cells in vitro [80,81]."
39027429
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"Knockdown of hERG1 significantly suppressed cellular proliferation and invasion, and induced apoptosis, while inhibition of hERG1 significantly decreased activation of NF-kappaB."
27076857
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"Reduced expression of the hERG protein by siRNA transfection resulted in decreased cell proliferation in small cell lung cancer cells [XREF_BIBR], and a hERG channel promoted the proliferation of ovarian cancer cells by affecting the cell cycle [XREF_BIBR]."
24434641
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"Increased hERG1b levels are expected to depolarize cells, while high hERG1 levels will shift membrane potential toward more hyperpolarized values 35 and suppress cell proliferation."
21850047
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"We found that the hERG blocker E-4031 decreased proliferation as assayed by sphere formation in a GPDC line exhibiting high levels of hERG expression, whereas blocking hERG in low hERG expressing lines does not decrease proliferation to the same extent."
27635088
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"To further evaluate whether silencing herg gene in SH-SY5Y cells may inhibit cell growth and proliferation, the growth curves of cells nontransfected and transfected with shRNA-herg1, shRNA-herg1/1b o[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17976575
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"In addition, leukemic cell proliferation was dramatically inhibited by HERG K+ channel special inhibitor E-4031."
17641836